The SensoTech Ultrasonic Analyzer for the Pharmaceutical Industry LiquiSonic® is an analytical system that determines the concentration of liquids directly in the production process, allowing for real-time measurement and thus allowing to verify the quality of production. In the pharmaceutical industry, the LiquiSonic system can be installed in different stages of the process: raw material control, concentration measurement, phase separation, solvent recovery, crystallization and suspension measurement.

Control of raw materials

For an optimal production result, a high quality of raw materials is required. Early detection of discrepancies or defective products leads to quick corrective actions and thus to excellent production. Furthermore, the substances supplied can be clearly identified and separated from product specific values ​​through the sonic velocity. With the LiquiSonic analyzer it is possible to carry out a simple and rapid monitoring of the products delivered directly to the incoming goods department. As in the process, the liquid is sampled directly at the point of delivery. In this way, contamination and fluctuations in product quality within the different batches can be detected immediately. In addition, the LiquiSonic ultrasonic analyzer is certified for potentially explosive atmospheres and can be used even when there are highly reactive substances.

Solvent recovery

Organic or aqueous solvents are used in many fields of the chemical industry. After their use they can be disposed of, which is usually very expensive, or they can be distilled and then reused in the process. Sometimes even fresh solvents do not meet the purity or concentration requirements. They can also be distilled to meet expectations. There are different distillation methods, each method differs in results, for example the columns ensure high purity and vacuum distillation is used for sensitive fluids. Typical solvents are acetone, ethanol, toluene, n-hexane or ethyl acetate, etc. It is important that the recycled solvents achieve the same qualities as the raw materials. Thus the quality of the product in the process remains consistently high. Ideally recyclates do not differ from fresh solvents, so the clean distilled fluid can be returned directly to the manufacturing process. Controlling the concentration of the distillate during recovery is an important step to reduce costs during distillation and to increase the availability of the solvent. Removing solvents (or other chemicals) that have been contaminated in the process is very expensive. Solvents can often be easily regenerated on site, reducing costs due to the decrease in the purchase of raw materials, the minimization of storage space, less effort in handling chemicals and much lower costs for disposal and transport. The LiquiSonic analyzer determines the concentration of the raw material and the recycled product in a reliable, precise and maintenance-free way. As a result we have: plant automation, greater distillation efficiency, optimal quality of the final product, increase in plant capacity, resource savings and sustainable use of the material. LiquiSonic provides accurate concentration measurement in line with real-time quality monitoring of the recycled solvent. Using the sonic rate the concentration can be monitored directly in the process allowing for a reproducible and quality product, eliminating the need for numerous samples to be analyzed in the laboratory. In addition, the robust construction of the sensor allows for a long process life. All measured data are saved in a long-term data memory, so that they can be used in audits and for the analysis of process disturbances. It is also possible to have the special material sensor such as Hastelloy C2000 if necessary or with ATEX or FM certifications.

Blend of 3 components

The LiquiSonic® measuring system allows the measurement of the concentration in tri-component mixtures. A 3-component mixture usually means a liquid composed of two substances in a carrier fluid or solvent. The measurement principle is based on the variations in concentration of the individual components of a liquid and on their influence on certain physical values ​​which appear to be different. For example, these physical values ​​include sonic speed, density, pH, refractive index or other known variables. If the concentration of two components changes in a carrier liquid, two physical values ​​are required to determine the concentration. If the relationship between the change in concentration and the change in values